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The advanced glycation end products (AGE) content in the plasma membrane of epithelial cells is directly increased by the conversion of the superoxide anion to hydrogen peroxide by SOD3, as seen in ( Figure 4 )

Cell Plasticity in Liver Regeneration

Cells were plated on 48-well plates, coated with anti-CD3 (1 g ml 1 ) and anti-CD28 (10 g ml 1 ) antibodies, in RPMI medium supplemented with 10% FCS, penicillin, streptomycin, HEPES, glutamine, pyruvate, nonessential amino acids and -mercaptoethanol diluted with PBS (1:1) in the presence of IL-12 (3 ng ml 1 , Peprotech) (T H 1 conditions)

Glutathione synthesis and its role in redox signaling

Activated T cells without GPX4 accumulate cellular lipid peroxides and undergo ferroptosis (21, 39, 40), while ferroptotic oxidative signals are produced primarily by iron-mediated Fenton reaction or enzymatic reaction via lipoxygenases or the dysregulated GSH antioxidant system (41, 42)