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Besides, the de-L-lactylase activity of HDACs 1 and 3 have been verified in cells

10.1038/s41467-020-20154-8 Nat

In esophageal squamous cell carcinoma, hypoxia inhibits ferritinophagy-mediated ferroptosis through the USP2 (ubiquitin specific peptidase 2)-NCOA4 (nuclear receptor coactivator 4) axis [79]

Figure 31 illustrates a fundamental hypothesis of pharmacology, namely, that a relationship exists between a beneficial or toxic effect of a drug and the concentration of the drug