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In addition to haemodynamic overload, uraemic toxin accumulation and altered ion homeostasis, which are known to underlie left ventricular hypertrophy in CKD and drive cardiac dysfunction, we examine the role of myocardial metabolic remodelling in CKD

Biomolecules 11:1426

These include cell differentiation, angiogenesis, inflammation, proliferation, vascular damage, and apoptosis

Early diagnosis, albeit challenging, is essential and may eliminate unnecessary surgical procedures, prevent further functional decline, and avoid excessive financial and time expense and inappropriate therapies

The LDDS test requires a 4-hour and 8-hour blood sample to be drawn after a dexamethasone injection has been given