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Future studies could test the hypothesis that the cancer-protective benefit of ferroptosis involves the reciprocal acceleration of aging

Polyphenols In Human Health and Disease

a , Representative fluorescence images of uN2C-polyGeGFP (polyGeGFP) or SV40-NLS-fused polyGeGFP (npolyG-eGFP) in HEK293T cells, and quantification of the percentage of intranuclear inclusions in each group ( n = 6 fields per group, 72 cells were analysed for polyGeGFP and 139 cells for npolyG-eGFP)

CAFs are key mediators of this process, increasing the extracellular cysteine supply in PDAC via their transsulfuration pathway to support the synthesis of glutathione (GSH) and prevent PDAC ferroptosis, a process activated by the TGF/SMAD3/ATF4 signaling pathway [91]