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found significantly decreased expression of autophagy markers, including Beclin1 and LC3, and increased p62 expression in stromal vascular fraction cells isolated from the adipose tissue of older mice (20 months) compared to that of younger mice (46 months) [84]

The enhancing effect of theobromine on the levels of acetylcholine-related enzymes, dopamine, and especially noradrenalin confirms its beneficial role on the cognitive reserve and, consequently, a possible reducing effect on the cognitive decline underlying aging and Alzheimers disease [216]

The gut microbiota in human energy homeostasis and obesity

The gene encoding a subunit of the cystine transporter SLC7A11 (xCT) is another Nrf2 target (Sasaki et al., 2002), whose product increases the availability of cysteine for glutathione synthesis