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Design, microwave synthesis, and molecular docking studies of catalpol crotonates as potential neuroprotective agent of diabetic encephalopathy

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Pharmacological blockade of GABA-ARs and GlyRs allows polysynaptic A-fiber input to NK1R-expressing projection neurons expressing NK1R become obvious, indicating that under disinhibition, non-noxious mechanical stimulation can activate the pain pathways and induce hyperalgesia