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Maeda et al., 1985), and is generally considered a prominent evolutionarily-conserved anti-aging strategy, with several studies demonstrating similar beneficial effects in multiple model organisms (reviewed in Fontana et al

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Retinoid discontinuation creates the benchmark comparison since topical vitamin A derivatives (tretinoin, adapalene, retinol) represent gold-standard anti-aging treatment with decades of research and user experience documenting post-treatment outcomes