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In a depressive-like monkey model, significant changes in the gut microbiota were observed, and lipidomic analysis revealed abnormal lipid metabolism in brain regions (171)

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BH4 acts both as a direct trap for small molecule free radicals and a cofactor for enzymes involved in CoQ10 synthesis, protecting phospholipids containing two polyunsaturated fatty acid (PUFA) tails from oxidative degradation during ferroptosis

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