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Abnormally spliced beta-globin mRNAs: a single point mutation generates transcripts sensitive and insensitive to nonsense-mediated mRNA decay

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Rather, elevated RDW reflects underlying pathophysiology that increases mortality risk including chronic inflammation (inflammatory cytokines impair red blood cell production and create heterogeneous cell populations), oxidative stress (damages red blood cells and bone marrow function), nutritional deficiencies (iron, B12, folate deficiencies create mixed cell populations and reflect poor overall nutritional status), bone marrow dysfunction (impaired or dysregulated red blood cell production), and poor overall physiological reserve