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Adhesion molecules and gene transfer

Oxidative stress is one of the most important mechanisms of increased cellular senescence and frailty, leading to a wide range of diseases that are common in the older population, including chronic lung disease, cardiovascular disease, chronic kidney disease, skeletal muscle dysfunction and cancer (188, 189)

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however, the application of these substances is impeded by notable limitations, which encompass skin irritation, the formidable barrier presented by the skin through physical modalities and alterations in skin integrity, which consequently restrict their widespread application within clinical settings [7]