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Polyphenols such as flavonoids and phenolic acids have shown promise in reducing oxidative stress and inflammation in experimental models of stroke (171)

Aguirre GA, De Ita JR, de la Garza RG, Castilla-Cortazar I (2016) Insulin-like growth factor-1 deficiency and metabolic syndrome

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The biologically active form is the (S,S) structure, while the (R,S) structure is biologically inactive

Blumenreich M, Andreeff M , Murphy ML, Young C, Clarkson B