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Gacci M, Corona G, Salvi M, et al

performed in vitro and in vivo experiments and found that high glucose levels can promote the generation of ROS in ECs by upregulating NOX4 (90)

J Amry Med Univ 2019;41:1947-53

Semax can be administered as a subcutaneous injection or as an intranasal spray, depending on the protocol

Consider medication review: If youre on a high-risk medication (mirtazapine, paroxetine, TCA) and have metabolic concerns: Discuss alternatives with your provider Ask if switching to a lower-risk option is feasible Many patients can successfully switch, but this requires careful planning (discussed below)