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Hence, by targeting the enzymatic activity of SARM1, inhibitors may effectively prevent the depletion of NAD + , thereby maintaining cellular energy homeostasis and enhancing neuronal resilience, potentially expanding the treatment landscape for various neurological conditions

These symptoms are especially common in older adults and can sometimes be mistaken for early signs of dementia or Alzheimer's disease

doi: 10.1152/ajpcell.00105.2009 45 RichelsenBPedersenSBKristensenKBrglumJDNrrelundHChristiansenJSet al