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Inspite of promising preclinical and observational data, their clinical translation remains limited due to challenges in bioavailability, lack of standardization, and possible herbdrug interactions

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Focusing on dynamic associations between metabolism and disease stages, longitudinal metabolomic cohort studies can track changes in metabolic profiles of patients from early asymptomatic stages to stable and acute exacerbation phasesidentifying core metabolic characteristics at different disease stages and addressing gaps in the current understanding of correlations between disease staging and metabolic abnormalities

Consulted in the Orthopaedic Department where synovectomy was recommended and performed

Segura-CamposMRPeralta-GonzlezFCastellanos-RuelasAChel-GuerreroLABetancur-AnconaDA