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The available treatments are all symptomatic, slowing disease progression and improving patient quality of life

The combination of afamelanotide implant plus NB-UVB achieved 48.6% repigmentation at day 168, compared to 33.3% with NB-UVB monotherapy a statistically significant and clinically meaningful difference (Lim et al., 2015)

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A number of studies using genetic approaches to suppress PKC signaling by using antisense oligonucleotides or by the targeted deletion in the whole body of mice have shown that inactivation of PKC protects against insulin resistance induced by short and long term high-fat diet feeding [49, 53, 54]