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After extensive lung injury, inflammatory exudations impede gas exchange and release large amounts of pro-angiogenic factors that promote angiogenesis (Ingbar, 2000)

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In a mice study, Gser et al

In particular, glucose-6-phosphate 1-dehydrogenase (G6PD), the rate-limiting enzyme of oxPPP, was significantly upregulated and is involved in the conversion of glucose 6-phosphate to 6-phosphoglucono-1,5-lactone, with concomitant production of NADPH [60]