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An increase in FFA efflux from adipose tissue to liver can result in insulin resistance in the liver and GH is known to antagonise insulin action by this mean [183]

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Full-text article Dimet-Wiley AL, Latham CM, Brightwell CR, et al

The recent discovery of pharmacological ABHD5 ligands that disrupt the interaction between ABHD5 and PLIN1 (48) demonstrate that the dissociation of ABHD5 is sufficient to stimulate adipocyte lipolysis and that these protein interactions can be targeted pharmacologically (34, 48, 49)