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Febuxostat febuxostat was FDA approved in 2009 for treating hyperuricemia in gout

In type 1 sequences the Cys residues are exclusively arranged in Cys-Xaa-Cys motifs (Xaa represents another amino acid) in both the N- and C-terminus, while type 2 have Cys-Cys, Cys-Xaa-Xaa-Cys, and Cys-Xaa-Cys sequences in the N-terminal domain and Cys-Xaa-Cys in the C-terminal domain

In contrast, HIF2 KO cells presented an accumulation of GSSG, indicating reduced capacity to overcome radiation-induced oxidative stress (Figure S7B)

Hung PH, Caldwell JB, James WD

DJ-1 is a neuroprotective protein involved in the regulation of antioxidant, anti-inflammatory and antiapoptotic pathways (Kahle et al