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Description

In conjunction with the mucosal layer and specialized cells, the epithelial layer forms a well-equipped, intricately regulated and stringent barrier with continuous scrutiny by immune cells to create an immune-silent environment

The reason for their expansion relies in the fact that they provide distinct resistance against Plasmodium falciparum malaria, the most dangerous, frequently deadly form of malaria

Therefore, developing and validating biomarkers that directly indicate neuronal ferroptosissuch as specific oxidized phospholipid profiles, ferroptosis-related proteins (e.g., released HMGB1, modified GPX4), or their metabolic fragmentsis crucial for enhancing clinical diagnostic and therapeutic monitoring capabilities

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