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76-78 Furthermore, intensive cholesterol lowering in patients with LDL-C levels at a baseline of less than 130 mg/dL (median value, 108 mg/dL) and increased C-reactive protein levels of greater than 2.0 mg/L (median value, 4.2 mg/L) (to convert to nmol/L, multiply by 9.524) significantly reduced the incidence of MI, stroke, revascularization, hospitalization for unstable angina, or death from cardiovascular causes in patients without clinical evidence of cardiovascular disease (hazard ratio, 0.56

Another observation poorly explained by our model is that in many sufferers, CVS episodes are regular by the calendar, both in terms of both time of the day regarding symptom onset (circadian cycle), and for time of the month/year regarding episode intervals (infradian cycle) (3, 71, 102104)

MiR-33 contributes to the regulation of cholesterol homeostasis

PMID 27126547

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