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The NRF2-dependent effect was identified through the antioxidative response element in target gene loci, while NRF2-independent effects act through DNA 5hmC modifications via the regulation of the metabolite L2HG

Chunduri L, Kurdekar A, Patnaik S, Dev BV, Rattan TM, Kamisetti V (2016) Carbon quantum dots from coconut husk: evaluation for antioxidant and cytotoxic activity