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IL-8 concentration levels, assessed using ELISA, revealed a significant increase in IL-8 secretion in both TC pBDMs and TC THP1 models at the 48 h time-point after CS exposure (Fig

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(2) Sarin exerts toxicity by irreversibly inhibiting acetylcholinesterase (AChE), resulting in accumulation of acetylcholine at cholinergic synapses and subsequent neuromuscular and respiratory dysfunction

Particularly, since at time of collection, this cohort appear to harbor overall similar levels of plasma-based amino acids, regardless of disease status or disease severity, indicating minimal differences in nutrition status

USA 110 , 1247412479 (2013)