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Description

The NOX isoforms have 6 transmembrane -helices, a heme region and a flavoprotein homology domain on the intracellular C terminal region that contains binding sites for flavin adenine dinucleotide (FAD) and NADPH [52]

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Dysregulation of this axis leads to a self-perpetuating cycle of inflammation, oxidative stress, and tissue damage

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Xia N, Zheng W, Jiang S, et al

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