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doi: 10.1016/j.bbrc.2020.12.048 53 Lammerts van BuerenJJakobsDKaldenhovenNRozaMHiddinghSMeestersJet al

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coli production introduces endotoxin risk that chemically synthesized shorter peptides do not carry

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10.1038/nature09572 67 HaatajaL.ArunagiriA.HassanA.ReganK.TsaiB.DhayalanB.et al (2021)

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Alternatively, covalent coupling of surface ligands is a crosslinking mechanism that requires a highly compact ligand layer with terminal functional groups

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The problem: very short half-life (~50 minutes) and 3 daily injections at meals , an extremely impractical regimen

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