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The interaction of BIM with anti-apoptotic BCL-2 homologs is especially critical when stress signals promote BIM expression, disturbing the balance between anti- and pro-apoptotic BCL-2 proteins, thereby favoring apoptosis

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Furthermore, great concern for the evidence suggesting that activation of 7nAChRs through some drugs or herbal medicine may impact brain function and clarify underlying molecular mechanisms, including oxidative stress, inflammation, and apoptosis