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89 Elevated EV concentrations in the peripheral blood of GBM patients, independent of specific molecular alterations (EGFR amplification, PTEN deletion, MGMT expression, and IDH mutations), 90 suggest their broad applicability in GBM detection, prognosis, and relapse prediction

Notable proteins, such as glial fibrillary acidic protein, brain-derived neurotrophic factor, protein S100B, and neural cell adhesion molecules, have been identified as neuronal markers linked to GBM pathology

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Healthy brain specimens were also acquired from patients during surgery for their tumor

Annu Rev Physiol 2016;78:22341