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The aim of this research, therefore, is to increase the effectiveness of the drug enabling a reduction in the dose and thus toxicity

these factors make GLP-1 RAs an alternative initial treatment option, with or without metformin based on glycemic needs, in T2DM patients with indicators of high-risk or established heart failure (HF) or CKD who cannot tolerate an SGLT2 inhibitor

Paradoxical effects of metalloporphyrins on doxorubicin-induced apoptosis: scavenging of reactive oxygen species versus induction of heme oxygenase-1

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Mechanistically, these protective effects can be attributed to diminished SMC necroptosis which leads to reduction in the release of proinflammatory cytokines and DAMPs [11] via rapid permeabilization of the cell membranes as well as preventing release of inflammatory mediators activating pattern recognition receptors (PPRs) on neutrophils and macrophages [39]