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While the pro-inflammatory effect of microcrystalline UA is well-established 3,20 , there are several indications that soluble UA free of UA crystals has protective effects against inflammatory mechanisms and toxicity 50 with effects on macrophage polarisation towards the anti-inflammatory M2 phenotype 51

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In mice fed a high-fat high-cholesterol diet, curcumin protected against the development of gallstones, and its effect was enhanced with the addition of piperine, an alkaloid from black pepper (Li 2015)

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