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These parallel pathways collectively intensify the proteotoxic and oxidative burdens, ultimately leading to irreversible cell death (Figure 3)

Post-surgical patients : Enhance healing and minimize scar tissue formation

Ferroptosis suppressor protein 1 (FSP1), a NAD(P)H-ubiquinone reductase and the second mainstay of ferroptosis control after glutathione peroxidase-4 4,5 , was found to efficiently reduce vitamin K to its hydroquinone, a potent radical-trapping antioxidant and inhibitor of (phospho)lipid peroxidation

In fact, GR and FK506 binding protein 5 (FKBP5) expression can be changed by the polyphenolic flavonoid icariin, which enhances GR stability and lessens GR sensitivity to GC in vivo (167)

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