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Stability of proteins: small globular proteins

Therapeutic approaches to address copper ion metabolism abnormalities and the associated cardiovascular diseases Despite high levels of research into the understanding of the role of copper physiologically and pathophysiologically, there remain uncertainties regarding the accurate measurement of copper levels and the long-term effects of copper exposure on cardiovascular health (118)

Dysfunction in key components of this network leads to the disruption of Cu homeostasis, resulting in fatal disorders such as Wilson disease, which is caused by mutations in the hepatic Cu efflux transporter ATP7B

Damiola, F