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Suarez et al., 2016)

[5] Gene expression can be controlled through the action of repressor proteins that attach to silencer regions of the DNA

[PMC free article: PMC7330478] [PubMed: 32470975] Substance Identification Substance Name Vitamin B 12 CAS Registry Number 68-19-9 Drug Class Breast Feeding Milk, Human Vitamin B Complex Vitamins Disclaimer: Information presented in this database is not meant as a substitute for professional judgment

revealed that in liver cancer, hypoxia activates MAT2A expression through hypoxia-inducible factor-1, resulting in increased MAT II enzyme activity and reduced SAM production, which then induces genomic DNA demethylation

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