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Endothelial injury generated directly by intracellular viral replication and by ACE2 downregulation, exposing cells to angiotensin II in the absence of the modulator effects of angiotensin 17 (270, 271), and vascular chronic inflammation promoting the development of tissue macrophages overloaded by cholesterol (foam cells), both increase the possibility of acquiring a severe COVID-19 infection (170, 209, 258, 259, 272, 273)

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This work was supported by a pilot grant from the HIV and Aging Grant CFAR-UAB (R24 AG044325), and a philanthropic donation received from the McNair Medical Institute at The Robert and Janice McNair Foundation.

Archived from the original on 26 March 2013

Effects of autochthonous strains mixture on gut microbiota and metabolic profile in cobia ( Rachycentron canadum )