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Conversely, exercise promotes neurogenesis, enhances synaptic plasticity, improves cognitive function, and reduces neurological disease incidence, making it a key intervention for treating central nervous system disorders and mitigating aging effects (Chow et al., 2022)

Parkin-mediated polyubiquitination then facilitates the interaction with autophagy receptors, ultimately leading to autophagosome formation and lysosomal degradation of dysfunctional mitochondria

Strongest Current Evidence CagriSema REDEFINE 1 and REDEFINE 2 are completed phase 3 trials published in NEJM with over 4,600 participants

& Rowe, M

Interestingly, BAC-Syn mice show increased leakage of fibrinogen especially in striatal regions [258]