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The aging process is linked to diminished synthesis and variety of IgA, along with compromised IgA binding specificity to gut bacteria, which disrupts the equilibrium between osteogenesis and osteoclastogenesis and potentially contributes to age-related OP

Mice were also intraperitoneally treated with 3 mg/kg bazedoxifene acetate (BZA) (MedchemExpress) or 10 mg/kg testosterone enanthate (TTE) (Fujifilm) dissolved in 100 l of corn oil, and 1 mg/kg GSK'074 (MedchemExpress), 2 mg/kg MitoQ (Selleck) dissolved in 100 l of 10% methylcellulose (Fujifilm) containing 0.01% tween-80 (Nacalai)

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