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The accumulation of WAT promotes the switching of anti-inflammatory M2 macrophages to pro-inflammatory M1 macrophages, exacerbating the inflammatory response [99]

Liang S, Xiong W, Yin C, Xie X, Jin YJ, Zhang S, et al

As discussed in the CY 2026 OPPS/ASC proposed rule, similar to our discussion in the economic analysis section of the FY 2021 IPPS/LTCH PPS final rule (85 FR 59089 through 59090) regarding the market-based MS-DRG relative weight methodology, once we have access to the weighted payer-specific negotiated charge information at the MS-DRG level from the cost reports we would be able to more precisely estimate the payment impact of adopting this market-based MS-DRG relative weight methodology for payments beginning in FY 2029

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