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Overall, capsaicin-activated TRP channels play a central role in cardiometabolic disease by coordinately regulating oxidative stress and inflammatory pathways, providing a strong mechanistic foundation for targeting this axis in disease prevention and treatment (112)

found that Que intake resulted in a 39% reduction in hepatic TG content and a 1.5-fold increase in VLDL in HFD-induced NAFLD rats ( in vivo and vitro and showed a significant decrease in serum transaminase levels, a recovery for liver superoxide dismutase, catalase and GSH levels, and a relieve in lipid accumulation ( via Que supplementation in mice

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Nevertheless, the SECIS element and the Sec-tRNA[Ser]Sec are the central components dictating selenocysteine insertion together with these associated proteins [8]

PPAR, in particular, is recognized as a central regulator of lipid metabolism