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In a high-risk cancer family, a hereditary nonsense mutation in BAP1 (Y646X) and exposure to asbestos and UV radiation in the environment were found to contribute significantly to the increased occurrence of cutaneous melanoma (195)

Moreover, inhibiting the transdifferentiation of kidney resident cells, such as fibroblasts, pericytes, tubular cells and endothelial cells, into myofibroblasts can negatively regulate tubulointerstitial fibrosis (156)

Antisense oligonucleotide-mediated MSH3 suppression reduces somatic CAG repeat expansion in huntington's disease iPSC-derived striatal neurons

Kraaij M D, Savage N D, Van Der Kooij S, W, et al

2007 Nov 28 [cited