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Iron is typically stored and transported as ferric iron (Fe 3+ ), and cells uptake iron through transferrin-dependent or transferrin-independent pathways (Johnsen et al., 2019)

The concentration of vitamin E in the brain is negatively correlated with the concentration of A in the brain (Morris et al., 2015) and can help reduce the accumulation of A in the rat brain and increase the clearance of A in the blood (Nishida et al., 2009)