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Beyond direct killing, LL-37 modulates host immunity: in murine sepsis models, it induced neutrophils to release microvesicles rich in antimicrobial proteins, lowering bacterial burden and improving survival [3]

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(2) Preparation of the intermediate ( S )-3 : a) Preparation of a chiral catalyst: Dichloro (4-methyl isopropyl benzene) ruthenium (II) dimer (0.006 mmol, 3.7 mg), and a chiral ligand ( S, S )-CsDPEN (0.013 mmol, 5.6 mg) were placed in a 25 mLreaction flask, into which was added water (0.6 mL) and stirred at 40C under nitrogen protection for 4 h to prepare the catalyst, ready for use