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Risperdone (RisperdalTM) which was approved by the FDA in 2006 for irritability (aggression, self-injury, temper tantrums, and rapid mood changes) in individuals with ASD, is the best studied

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Inhibition of pyruvate dehydrogenase kinase 2 protects against hepatic steatosis through modulation of tricarboxylic acid cycle anaplerosis and ketogenesis