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In contrast, for those diseases caused by NRF2 loss of function or a defect in one of the NRF2-regulated pathways, reactivating an alternative pathway that could also contribute to ROS detoxification might be a way to resolve the problem

doi:10.1093/jn/133.6.2068S

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Statistics show that globally, PE accounts for at least 46,000 maternal and 500,000 perinatal deaths annually, with its incidence and mortality rates increasing each year 2

Schell JC, Olson KA, Jiang L, Hawkins AJ, Van Vranken JG, Xie J, et al