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Gastrointestinal absorption of vitamin B 12depends on the presence of sufficient intrinsic factor and calcium ions

For long-term benefits, such as improvements in fatigue, cognitive function, and overall well-being, it may take a few weeks to months of regular B12 injections

This longevity of research interest is itself informative: compounds that fail to replicate across independent laboratories typically disappear from the literature within a decade

The occurrence rate of CTLN2-induced Citrin deficiency was most recently reported in France, UK and Canada, which implies that CD has now emerged as a pan-ethnic disease worldwide [135, 136]

Eating fortified cereals and/or taking multivitamin supplements may eliminate some B12 deficiency in this population 1,2 but yearly uMMA screening is still warranted