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These two drugs have been found to display competitive blocking effect in short-term kinetic, whereas long-term reaction analysis revealed their irreversible inhibitory effect by forming a stable complex of enzyme-bound intermediates [91]

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Mice were chronically exposed to filtered air for control group or to CS (20 cigarettestwice/day, 6 days/week) from Marlboro cigarettes (Philip Morris Companies, 0.8 mg of nicotine, 10 mg of tar, and 10 mg of carbon monoxide per cigarette) for the other groups

NFjB and Nrf2 mediated neuroinflammatory pathways are mainly responsible for mitochondrial dysfunction and ultimately cause progressive neurodegeneration in all NDs

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