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Inhibition of Cdc42 activity extends lifespan and decreases circulating inflammatory cytokines in aged female C57BL/6 mice

[17] AlaRS, GlyRS, LeuRS, IleRS and ValRS are the most evolutionarily stable members of the family

This observation raises the question of whether they have additional, discrete roles

Neurodegenerative diseases have been linked to microglia hyperactivation, and in vitro cultures, IL-10 has been demonstrated to prevent microglia and other glia from producing proinflammatory cytokines [38]