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When mitochondrial function is impaired, enzyme complex IV in the inner mitochondrial membrane fails to produce water as it should, resulting in the production of O 2 -, which subsequently convert into OH and H 2 O 2

Yousef AM, Farhad R, Alshamaseen D, Alsheikh A, Zawiah M, Kadi T (2019) Folate pathway genetic polymorphisms modulate methotrexate-induced toxicity in childhood acute lymphoblastic leukemia

Myth: "More is always better when it comes to antioxidants." Fact: The body thrives on balance

Acute hemodynamic effects of singledose sildenafil when added to established bosentan therapy in patients with pulmonary arterial hypertension: results of the COMPASS1 study