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High fructose corn syrup, a common ingredient used as a sweetener in many processed foods and beverages, has also been found to promote intestinal tumor growth in experimental models, although more research, including epidemiological data in humans, is warranted (241)

2.2 Metformin alleviates endoplasmic reticulum (ER) stress ER stress refers to a homeostatic imbalance within the ER caused by external stimulus or changes in the intracellular environment, which further leads to the accumulation of unfolded or misfolded proteins in the ER

Mercury salts affect mainly the gastrointestinal tract (GIT) and kidneys, and cause acute tubular necrosis, immunological glomerulonephritis or nephrotic syndrome after prolonged exposure

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Several factors, including cytokines, proteases, growth factors, gut microbiota, and dietary components are known to regulate intestinal TJs opening ( Intestinal epithelial cells and mononuclear phagocytes sense bacteria or their products mainly through pattern recognition receptors such as TLRs (166)