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The vitamin is absorbed in two ways: Active through a special transport molecule (intrinsic factor) saturated at approximately 1.5g per dose/meal Passive through vitamin B12 that passes through the intestinal wall without a transport molecule maximum 1% of the supplied dosage The real intake is calculated through the combination of these two mechanisms

Huang, P., Chandra, V

But when this gene has a mutation (which roughly 2540% of the population may carry), it can slow or block this conversion

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Treating Vitamin B12 Deficiency with Supplements How High Should Vitamin B12 Dosages be