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It is unclear if this is due to the limited number of patients examined at a molecular level, or to the fact that variations in the extracellular domain have limited functional significance, or perhaps because the phenotype produced by extracellular mutations differs from the classic phenotype, with patients escaping ascertainment

6 The increasing incidence of erectile dysfunction with age probably relates to the increasing prevalence of Peyronies disease with age, as the loss of stiffness or axial rigidity of the penis causes minor flexion injury during normal sexual activity

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TMLHE mutations are surprisingly common Two recent studies have found that the prevalence of TMLHE mutations in human populations may range from about 1 in 350 to about 1 in 900

Journal of the American College of Cardiology, 70 (1), 101113