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This Review will discuss specific PDTX disease examples illustrating an overview of the opportunities and limitations of these models in cancer drug development, and describe concepts regarding predictive biomarker development and future applications

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BMJ 301 , 853855 (1990)

Neurological And Psychiatric Adverse Reactions Neurological and Psychiatric adverse reactions outside of dizziness, somnolence, insomnia, and anxiety listed above can include headache, blurred vision, mydriasis, vertigo, tinnitus, tremor, paraesthesias, disturbances in attention, irritability, nervousness, and abnormal dreams

In BSO treated cells (figure 5C) nuclear CMFDA staining remains high during the time of culture, as high as in untreated fibroblasts, showing a proliferation curve very similar to the one shown in controls