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Discovered in 1977 by Schoenenberger and Monnier Using rabbit cerebral venous blood, it modulates delta wave sleep architecture and circadian signaling

Also, TTC occurred in some patients after injection with epinephrine [14-17]

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furthermore, this sex difference persisted in female Bmal1 knockout mice that displayed increased core infarct size compared to wild type females (Wiebking et al., 2013)